A Genetic Link between Obesity and MMP14-Dependent Adipogenic Collagen Turnover Running title: MMP14 Links ECM Remodeling and Obesity
نویسندگان
چکیده
Division of Metabolism, Endocrinology & Diabetes (MEND), Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109 USA Frontier Research Initiative, Institute of Medical Sciences, University of Tokyo, Tokyo, 1088639, Japan Department of Bioscience, National Cardiovascular Center Research Institute, Suita, 565-8565 Japan Department of Atherosclerosis and Diabetes, National Cardiovascular Center, Suita, 565-8565 Japan Department of Preventive Cardiology, National Cardiovascular Center, Osaka, Japan Division of Molecular Medicine & Genetics (MMG), Life Sciences Institute, University of Michigan, Ann Arbor, MI, 48109 USA
منابع مشابه
Genetic Link Between Obesity and MMP14-Dependent Adipogenic Collagen Turnover
OBJECTIVE In white adipose tissue, adipocytes and adipocyte precursor cells are enmeshed in a dense network of type I collagen fibrils. The fate of this pericellular collagenous web in diet-induced obesity, however, is unknown. This study seeks to identify the genetic underpinnings of proteolytic collagen turnover and their association with obesity progression in mice and humans. RESEARCH DES...
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